Insulin analogues are the most recent biotechnology products used in the treatment of diabetes and are designed to have absorption profiles that more nearly mimic the action of normal insulin production by the body than synthetic ‘human’ insulin. However, analogues differ in their biological effects with unknown consequences, such as their effects on:
• Mitogenicity [promotion of division and proliferation of any cell, including tumour cells]
• Apoptosis [see glossary].
• Glucose and lipid metabolism.
• Thrombocyte function.
• Protein degradation.